The present invention concerns chemical compounds combining affinity and antagonism against the human m3 muscarinic receptor with activity as selective phosphodiesterase IV (PDE IV) inhibitors, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.

 
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< Combination of dpp iv inhibitor and a cardiovascular compound

< N-aryl azaspiroalkene and azaspiroalkane compounds and methods of preparation and use thereof

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