Methods of synthesizing pure enantiomers of acylanalides such as Casodex
(bicalutamide) and its derivatives utilizing a compound having a ring structure
that, when opened, provides a substituent having the structure of Formula I:
##STR1##
wherein
- R1 is alkyl or haloalkyl having up to 4 carbons;
- R2 is alkyl having up to 6 carbon atoms; and
- R3 is CH2OR4 where R4 is
hydrogen or benzyl, C(O)CH3, or C(O)OR5 where R5 is
hydrogen or alkyl;
are disclosed.
