A two-lumen catheter for distal protection in percutaneous coronary and peripherical intervention comprises a tubular body defining a first lumen for allowing a guide wire to pass therethrough and a second lumen for connection to a sucking assembly, and being characterized in that said catheter further comprises an end portion defining tapering portion between the tubular body and the catheter tip, in said tapering portion being provided at least a hole communicating with the second lumen.