The present invention relates to fusion polypeptides including (a) a binding site for a cytoskeleton component and (b.sub.1) an effector protein or the catalytic domain thereof or (b.sub.2) a binding site for the effector protein, and nucleic acid sequences encoding the fusion polypeptides. Moreover, various therapeutic uses of the fusion polypeptides are described, e.g., the treatment of diseases associated with the presence of an aberrant cell population, preferably cancer or AIDS.

 
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