N,N-bis(3-aminopropyl)cyclohexane-1,4-diamine,
of formula (I), is a new compound that is prepared by hydrogenation with Raney
nickel catalyst of N,N-bis(2-cyanoethyl)-cyclohexane-1,4-diamine, the latter
being prepared by reaction between 1,4-cyclohexanediamine and acrylonitrile. The
oral administration to genetically alcoholic rats (from the strain UChB of the
University of Chile) of the tetrametanesulfonate monohydrate of (I) causes a significant
reduction in the alcohol consumption. The activity lasts for some time after the
treatment period. Besides, there is a virtually null disulfiram-like adverse effect,
what constitutes an advantage over the unpleasant use of some anti-alcoholism agents,
such as calcium cyanamide or disulfiram itself. Therefore, the compounds of the
invention are useful for the preparation of medicaments for the therapeutic and/or
prophylactic treatment of alcoholism in mammals, including human beings
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