The present invention consists of a new and unique ergonomic handgrip with separate ulnar and radial support means that divides the pressure between the heel of the hand and the thumb area along with removing the pressure in the central palmer crease at the joining of the wrist. This is accomplished by using a dog-bone shape with an ulnar or heel support area having a cavity conforming to the shape of the heel of the hand and a radial or thumb support with a cavity conforming to the shape of the thumb of the hand where it joins the wrist. The ulnar or heel support and the radial or thumb support are angled so as to keep the wrist in a neutral position in relation to the device and are divided by a median groove that blends up into the gripping area of the device. The median groove maintains a space between the device and the carpel tunnel or central palmer area of the hand. By adapting the conventional computer mouse to the shape of the ergonomic handgrip with separate ulnar and radial support means, some or all of the wrist pain can be eliminated.