Devices for removing and separating moisture from interior passage of woodwind musical instruments are disclosed. According to one aspect of the present invention, 1) a de-moisturizing device includes a pocket sewed onto one side of the device to provide storage for the device hanging outside of an instrument carrying case, thus keeping the moisture absorbed by the swab re-moisturize the instrument; 2) a de-moisturizing device contains a closed loop affixed at one end of the device for holding a moisture absorbent fabric for removing moisture from the interior passage of woodwind instruments; and 3) a de-moisturizing device contains a plurality of moisture absorbent desiccant gels in an elongated hollow porous tube for removing moisture from the musical instruments.