Disclosed are compounds represented by formula (I) which have triglyceride
biosynthesis inhibitory activity in the liver and inhibitory activity against the
secretion of apolipoprotein B-containing lipoprotein from the liver and particularly
have excellent inhibitory activity against the secretion of apolipoprotein B-containing
lipoprotein, are free from side effect of accumulation of lipids in the liver,
and are useful for the treatment and prevention of hyperlipidemia and arteriosclerotic
diseases. In formula (I), R1 and R2 represent alkyl, alkoxy,
cycloalkyl, phenyl, alkenyl, alkynyl, or a five- or six-membered saturated or unsaturated
heterocyclic ring, or R1 and R2, together with a nitrogen
atom to which R1 and R2 are attached, may form a ring; R3
and R4 represent a hydrogen atom, alkyl, a halogen atom, hydroxyl,
nitrile, alkoxycarbonyl, alkoxy, or carboxyl; or R2 and R3 may
be attached to each other to form —(CH2)m—, —NCH—,
—CHN—, or —(C1-6 alkyl)CN—;
A, D, E, and G each represent a carbon atom, or any one of A, D, E, and G represents
a nitrogen atom with the other three each representing a carbon atom; Q represents
a nitrogen atom or a carbon atom; Y represents a group represented by formula (II)
wherein X represents a hydrogen atom, group —C(O)N(R5)R6
or group —C(O)OR7, R8 is absent or represents
a bond, an oxygen atom, a sulfur atom, —SO2—, —SO—,
—CH2—CH2—, or —CHCH—,
and R9 and R10 represent a hydrogen atom, alkyl, alkoxy,
a halogen atom, or hydroxyl; and Z represents —(CH2)n—,
—O—(CH2)i—, or —C(O)NH—(CH2)i—
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