A reconfigurable cartridge processing module for use in a data storage system may comprise a frame having a plurality of sets of mounting locations provided thereon so that the frame defines a first component configuration and a second component configuration. In the first component configuration, a first cartridge receiving device is mounted to a first set of the plurality of sets of mounting locations provided on the frame so that the first cartridge receiving device is located at a first position within the frame. A second cartridge receiving device is mounted to a second set of the plurality of sets of mounting locations provided on the frame so that the second cartridge receiving device is located at a second position within the frame. In the second component configuration, a third cartridge receiving device replaces the first and second cartridge receiving devices and is mounted to a third set of the plurality of sets of mounting locations provided on the frame.