An indole derivative compound represented by formula (I) (wherein the
symbols in the formula are as mentioned in the specification) and a salt
thereof Since the compounds represented by formula (I) binds to PGD.sub.2
receptors and shows antagonistic activity, they are believed to be useful
for prevention and/or treatment of diseases such as allergic disease
(such as allergic rhinitis, allergic conjunctivitis, atopic dermatitis,
bronchial asthma and food allergy), systemic mastocytosis, systemic mast
cell activating disorder, anaphylaxis shock, airway contraction,
urticaria, eczema, diseases accompanied by itch (such as atopic
dermatitis, urticaria), diseases (such as cataract, retinal detachment,
inflammation, infection and sleep disorder) which are generated
secondarily as a result of behavior accompanied by itch (such as
scratching and beating), inflammation, chronic obstructive pulmonary
diseases, ischemic reperfusion injury, cerebrovascular accident,
autoimmune disease, chronic articular rheumatism, pleuritis, ulcerative
colitis and irritable bowel syndrome.