The present invention relates to agent for suppressing infection and proliferation
of human immunodeficiency syndrome virus (HIV-1), which infects immunocompetent
cells such as macrophage or dendritic cell and causes destruction of immune system,
and use of known compounds, macrolide derivatives for suppression of infection
and proliferation of human immunodeficiency syndrome virus in M type macrophage
derived from human monocytes. The present invention is useful for treatment of
patients with HIV-1 infection by low cost chemotherapeutic agents, and in addition,
is clinically used as supplement agent in HAART.