A method is provided for the localized intravascular administration of a fibrinolytic
metalloproteinase to a human subject in amounts that are both safe and effective
to lyse an occluding fibrin-containing blood clot, while also avoiding the neutralizing
effects of 2-macroglobulin in the circulating blood. A method
is also provided for the treatment of a blood clot in, around or attached to an
indwelling vascular access device. A method for restoring patency and function
of an indwelling vascular access device is also provided.
