A system and a method for applying RFID (Radio Frequency Identification) and PKI (Public Key Infrastructure) technologies for patient health safety to install RFID tag and RFID reader on the medicine-storing appliance. By sensing the RFID tag on medicine, the RFID reader stores the medical records such as medicine usage and movement, and transmit to central database. In this way, the circulation of medicine could be controlled, the improper use and distribution of medicines could be avoided, the medical resource management could be improved, and it could ensure that the correct medicine to enhance the process of five rights (right time, right route, right dose, right patient and right drug) and improve the quality of patient safety.