A device is provided for simulating a human skin microclimate and for measuring conditions such as temperature and humidity in the simulated microclimate. The microclimate is formed, for example, with fluids, gases and/or heat in a chamber of the device or between a surface of the device and a material disposed about the surface. In one aspect, a sensor is placed in the chamber to sense the microclimate. Methods of using the device and measuring microclimate conditions are also provided.