A shoe tightening device is provided for use with a shoe that includes a pair of eyelet tabs each having eyelets. The shoe tightening device includes a pair of lace units, a clamp unit, and a pull lace. Each of the lace units includes connecting end portions, operating end portions, intermediate portions, and anchoring elements adapted to be anchored removably on the eyelet tabs at corresponding ones of the eyelets. The clamp unit removably clamps at least one of the lace units, and includes at least one flexible string section, and at least one clamp member. The clamp member is slidable along the flexible string section between a clamping position and a releasing position. The pull lace is connected to the flexible string section for pulling the flexible string section so that the clamp member can slide along the flexible string section to the releasing position.