The disclosed technology enables electronic messages generated by one software application program to be routed to another remote software application program via a middleware oriented messaging ("MOM") infrastructure using named/labeled routing nodes and queues. Network connection information corresponding to particular routing nodes and queues can be automatically and dynamically determined by periodically, and/or upon the occurrence of an event, transmitting/receiving informational messages between software processes associated with known/previously-encountered routing nodes and queues. The routing nodes and queues can be identified by names or labels, which can be dynamically mapped to network connection information at runtime in the event of an addition, deletion, or modification to a processor cluster via the information contained in the informational messages.