A method and apparatus for providing compiler transformation of code using regions with simplified data and control flow and value specialization are described. In one embodiment, the method includes identifying in the code a plurality of potential candidates for value specialization, selecting a group of candidates from the plurality of potential candidates based on a value profile associated with each potential candidate, and determining specialized data for each selected candidate using a corresponding value profile. The method further includes forming a plurality of optimized regions based on corresponding specialized data. Each optimized region includes one or more selected candidates.