The present invention relates to peptides or peptide derivatives of the 65 kD lower matrix phoshpoprotein of human cytomegalovirus. The peptides disclosed are useful for determining whether subjects have been exposed to human cytomegalovirus. Methods for using these peptides or derivatives thereof to determine the peptide-induced production of interferon- and/or TNF- in CD8+ T cells isolated from subjects are also disclosed.

 
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> Hydantoin derivatives as inhibitors of matrix metalloproteinases and/or TNF- converting enzyme (TACE)

> Inhibition of vacuolar proton ATPase activity and/or the modulation of acidic organelle function sensitizes cells to radiation, chemotherapy and biological agents
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