The present invention relates to carbapenems and provides a compound of the formula
(I):
##STR1##
or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof wherein:
- R1 is 1-hydroxyethyl, 1-fluoroethyl or hydroxymethyl;
- R2 is hydrogen or C1-4alkyl;
- R3 is hydrogen or C1-4alkyl;
- R4 and R5 are the same or different and are selected
from hydrogen, halo, cyano, C1-4alkyl, nitro, hydroxy, carboxy, C1-4alkoxy,
C1-4alkoxycarbonyl, aminosulphonyl, C1-4alkylaminosulphonyl,
di-C1-4-alkylaminosulphonyl, carbamoyl, C1-4alkylcarbamoyl,
di-C1-4-alkylcarbamoyl, trifluoromethyl, sulphonic acid, amino, C1-4alkylamino,
di-C1-4alkylamino, C1-4alkanoylamino, C1-4alkanoyl(N—C1-4alkyl)amino, C1-4alkanesulphonamido
and C1-4alkylS(O)n— wherein n is zero, one or two:
with the proviso that there is no hydroxy or carboxy substituent in a position
ortho to the link to —NR3—. Processes for their preparation,
intermediates in their preparation, their use as therapeutic agents and pharmaceutical
compositions containing them.
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