A system and method for transferring data over an external transmission medium. A host computer is coupled to a device through a serial bus. A transfer object is configurable to encapsulate data transfer-related functionality, providing a generic interface for transmission of data over a variety of external transmission media and protocols. A user makes one or more transfer requests. Transfer objects corresponding to each request are built and linked together to form a sequential chain. The requests of the transfer objects are executed sequentially. If the current transfer object is the first in the chain, the request is executed on a current thread at passive level or higher, otherwise the request is executed on a system (kernel) thread at dispatch level. When a response to the request returns, control is returned to the current transfer object. The process is repeated until all transfer objects are processed.