ACE-2 inhibitors for the treatment of body weight and related disorders are
disclosed. ACE-2 inhibitors include peptides and small molecules. Examples of small
molecule ACE-2 inhibitors include compounds of formula (I):
Z- (I)
Wherein Z is a zinc coordinating moiety and is an amino-acid mimicking
moiety, and pharmaceutically acceptabale salts thereof. Methods of using the inhibitors
and pharmaceutical compositions containing the inhibitors to treat a body weight
disorder, to decrease appetite, to increase muscle mass, to decrease body fat,
to treat diabetes and to treat a state associated with altered lipid metabolism,
are also described.