An image comparison apparatus includes an observation image capturing means for capturing at least one of a macroscopic observation image of a specimen and a microscopic observation image of the specimen, a photographing means for photographing an observation image captured by the observation image capturing means, a recording means for recording a reference image prepared in advance, and a display means for displaying the observation image photographed by the photographing means as a comparison image, and also displaying the reference image recorded on the recording means on the display means so as to allow comparison between the comparison image and the reference image.