A zoom lens barrel comprises an exterior unit, which mainly forms an exterior portion, an optical unit having an image pickup optical system built therein, and a control unit and can be detachably mounted on a single-lens reflex camera. The optical unit includes first and second group lenses as the image pickup optical system, which can move forward and rearward in zooming and focusing, and a third group lens which can move forward and rearward in zooming. Particularly, in focusing, a first group lens holding frame for holding the first group lens and a second group lens holding frame for holding the second group lens are driven forward and rearward in a different amount in an optical axis direction through a cam follower and two cam grooves by driving a focus ring in rotation, thereby focusing is executed. The lens barrel can cope with a forward/rearward movement required in zooming and focusing and can be reduced in size.