Restenosis is inhibited through local delivery of anti-restenotic agents
including angiotensin converting enzyme inhibitors; nicotine receptor agonists,
agents that increase concentrations of nitric oxide, anti-angiogenic agents, agonists
of the TGF-beta receptor; death domain receptor ligands; and thrombin inhibitors.
In one embodiment of the invention, the localized delivery is effected through
the use of a stent modified for delivery of the agent at the site of injury from
balloon angioplasty.