A puncture and cut resistant surgical glove is provided for protection against injury from sharp surgical instruments and needles. The puncture and cut resistant surgical glove includes overlaid arrays of adjacent substantially spherical macrospheres. Each macrosphere has capture devices for capturing the point of a sharp instrument. An elastomer encapsulates the overlaid arrays of adjacent macrospheres. Each macrosphere is either porous or formed of smaller microspheres that are aggregated together to provide capture devices. A polymer is coated over the aggregated microspheres to give each macrosphere a smooth surface. The polymer and microspheres provide a capture function for capturing the points of sharp instruments. The puncture and cut resistant surgical glove can be fabricated using low cost manufacturing methods.