Compounds of formula (Ia) and (Ib) wherein A is CH2, or a single
bond; R2 is selected from: R, OH, OR, CO2H, CO2R,
COH, COR, SO2R, CN; R6, R7 and R9 are
independently selected from H, R, OH, OR, halo, amino, NHR, nitro, Me3Sn;
and R8 is selected from H, R, OH, OR, halo, amino, NHR, nitro, Me3Sn,
where R is as defined above, or the compound is a dimer with each monomer being
the same or different and being of formula (Ia) or (Ib), where the R8 groups
of the monomers form together a bridge having the formula —X—R—X—
linking the monomers, where R is an alkylene chain containing from 3 to
12 carbon atoms, which chain may be interrupted by one or more hetero-atoms and/or
aromatic rings and may contain one or more carbon—carbon double or triple
bonds, and each X is independently selected from O, S, or N; except that in a compound
of formula (Ia) when A is a single bond, then R2 is not CHCH(CONH2)
or CHCH(CONMe2). Other related compounds are also disclosed
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