Sensors (10, 110, 210, 310, 410) and a method for detecting an analyte
are described. Sensors (10, 110, 210, 310, 410) each have a volume of a
hydrophilic medium (24) that retains an amount of analyte proportionate
to the concentration of analyte in a biological fluid, electrodes (12) and
a redox enzyme in contact with medium (24), and an electron transfer mediator.
The fluid contacts sensors (10, 110, 210, 310, 410) and at initially predetermined
intervals intermittently applies a potential to electrode (12) sufficient
to oxidize the mediator and sensing current through electrode (12) as a
function of the duration of the applied potential. The applied mediator oxidizing
applied potential is maintained for a period of time sufficient to determine the
rate of change of current with time through electrode (12). The current
flow is correlated with the current flow for known concentrations of the analyte
in medium (24).