A fluid bed granulation process for manufacturing non-hygroscopic, stable granulates containing a water-soluble salt of S-adenosylmethionine is described. Said process comprises:

• a) the simultaneous, sequential or alternate dispersion of at least a solution of a water-soluble salt of SAMe (A) and of a solution of a coating agent (B), on a fluid bed granulation carrier (C) and
• b) the fluid bed granulation of the mixture.

Granulates obtainable by said process and solid oral pharmaceutical forms obtainable by said granulates are disclosed.