An RFID tag has a frequency agile RF transceiver that transmits data from the RFID tag to a reader and a direct sequence spread spectrum RF receiver that receives communications from the reader. Messages between the reader and the RFID tag are divided into frames, and each frame contains a frame header transmitted by the reader and at least one time slot containing data transmitted by the RFID tag. The frame header contains a hop sequence and a frequency in a hop sequence to be used by the RFID tag in transmitting data to the reader.