The present invention includes a method and apparatus to transplant functional cells into failing heart muscle to cure heart disease. In particular, the present invention relates to a method and apparatus to deliver cell-composed medical device and/or three-dimensional cell composite per minimally invasive intracornonary approach to the infarct-related artery, allowing functional cells to home in and engraft to the zone of the infarct and peri-infarct tissue, in order to regenerate infarcted, scarred or non-functioning myocardial tissue into functioning muscle ("myogenesis"), also to create growth and proliferation of new blood vessel ("angiogenesis") in the area.