Reagents which regulate human protein phosphatase IIC-like enzyme-like enzyme activity and reagents which bind to human protein phosphatase IIC-like enzyme-like enzyme gene products can be used, inter alia, to treat disorders associated with an increase in apoptosis, including AIDS and other infectious or genetic immunodeficiencies, neurodegenerative diseases, myelodysplasia, ischemic injuries, toxin-induced diseases, wasting diseases, viral infections, and osteoporosis. Regulation of human protein phosphatase IIC-like enzyme-like enzyme also can be used to treat disorders associated with a decrease in apoptosis, including cancer, diabetes, CNS disorders, cardiovascular disorders, chronic obstructive pulmonary diseases, and inflammatory disorders also can be treated.