Aircraft frames having multiple bracket mounting holes, corresponding brackets, and associated methods are disclosed. An aircraft frame member in accordance with one embodiment of the invention includes multiple sets of mounting holes, each set having one or more mounting holes. Brackets in accordance with an embodiment of the invention can be attached to either of at least two of the sets of mounting holes, for example, using snap fit attachment devices or other attachment devices. Each bracket can support one or more components (e.g., insulation, wiring, ECS ducting) relative to the aircraft frame member. The bracket can also span between two or more aircraft frame members. Each bracket can be installed in any of a variety of positions without the use of tools and can support any of a variety of devices. Accordingly, the time and cost associated with manufacturing, inventorying, installing and repositioning the brackets and the devices they support can be reduced.