The present invention relates to the delivery of alprazolam, estazolam,
midazolam or triazolam through an inhalation route. Specifically, it
relates to aerosols containing alprazolam, estazolam, midazolam or
triazolam that are used in inhalation therapy. In a method aspect of the
present invention, alprazolam, estazolam, midazolam or triazolam is
administered to a patient through an inhalation route. The method
comprises: a) heating a thin layer of alprazolam, estazolam, midazolam or
triazolam, on a solid support to form a vapor; and, b) passing air
through the heated vapor to produce aerosol particles having less than 5%
drug degradation products. In a kit aspect of the present invention, a
kit for delivering alprazolam, estazolam, midazolam or triazolam through
an inhalation route is provided which comprises: a) a thin coating of an
alprazolam, estazolam, midazolam, or triazolam composition and b) a
device for dispensing said thin coating as a condensation aerosol.