Compounds of the formula ##STR00001## or a pharmaceutically acceptable
salt or isomer thereof, wherein: Q, X and Z are CH or N; R, R.sup.4
R.sup.7 and R.sup.13 are H or alkyl; R.sup.1 is H, alkyl, fluoroalkyl,
R.sup.9-arylalkyl, R.sup.9-heteroarylalkyl, alkyl-SO.sub.2--,
cycloalkyl-SO.sub.2--, fluoroalkyl-SO.sub.2--, R.sup.9-aryl-SO.sub.2--,
R.sup.9-heteroaryl-SO.sub.2--, N(R.sup.22)(R.sup.23)--SO.sub.2--,
alkyl-C(O)--, cycloalkyl-C(O)--, fluoroalkyl-C(O)--, R.sup.9-aryl-C(O)--,
NH-alkyl-C(O)-- or R.sup.9-aryl-NH--C(O)--; R.sup.2 is H and R.sup.3 is
H, alkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, R.sup.9-aryl,
R.sup.9-arylalkyl, R.sup.9-heteroaryl, or R.sup.9-heteroarylalkyl, and
when X and Z are each CH, R.sup.3 is alkoxy, R.sup.9-aryloxy,
R.sup.9-heteroaryloxy, alkylC(O)O--, alkylaminoC(O)O--,
alkylC(O)NR.sup.13--, alkylOC(O)NR.sup.13-- or alkylaminoC(O)NR.sup.13--;
or R.sup.2 and R.sup.3 together are .dbd.O, .dbd.NOR.sup.10,
.dbd.N--NR.sup.11R.sup.12 or .dbd.CH-alkyl; R.sup.8 is substituted
phenyl, substituted heteroaryl, naphthyl, fluorenyl, diphenymethyl,
alpha-substituted benzyl or alpha-substituted heteroarylmethyl; R.sup.9
R.sup.12 are as defined; are disclosed for the treatment of HIV, solid
organ transplant rejection, graft v. host disease, inflammatory diseases,
atopic dermatitis, asthma, allergies or multiple sclerosis, as well as
pharmaceutical compositions and combinations with antiviral or
anti-inflammatory agents.
