Method and apparatus for communication within a programmable logic device using serial transceivers is described. In an example, an integrated circuit includes a first module and a second module. The first module and the second module each include a transceiver coupled to a serial/parallel interface, with each transceiver configured with at least one signal conductor for serial communication between the first module and the second module. The first module and the second module are configured to communicate with one another asynchronously. Each transceiver is configured to communicate with its respective serial/parallel interface in a synchronous time domain.