An implantable prosthesis, for example a stent, is provided having one or more elements that form the body structure of the prosthesis. The elements have a width that is variable from a nominal or conventional width to an increased width. The elements can have depots formed in the elements and are generally located at the increased width portions of the elements. Substances such as therapeutic substances, polymeric materials, polymeric materials containing therapeutic substances, radioactive isotopes, and radiopaque materials can be deposited into the depots.