The present invention relates to cyclic amine derivatives of formula(l) wherein R represents halogen, C.sub.1-4 alkyl, cyano, C.sub.1-4 alkoxy, trifluoromethyl or trifluoromethoxy; R.sub.1 represents hydrogen, halogen, C.sub.3-7cycloalkyl, hydroxy, nitro, cyano or C.sub.1-4 alkyl optionally substituted by halogen, cyano or C.sub.1-4 alkoxy; R.sub.2 represents hydrogen or C.sub.1-4 alkyl; R.sub.3 and R.sub.4 independently represent hydrogen, cyano, C.sub.1-4 alkyl or R.sub.3 together with R.sub.4 represents C.sub.3-7 cycloalkyl; R.sub.5 represents trifluoromethyl, S(O).sub.t C.sub.1-4 alkyl, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, trifluoromethoxy, halogen or cyano; R.sub.6 represents hydrogen or (CH.sub.2)rR.sub.7; R.sub.7 represents hydrogen, C.sub.3.sub.7 cycloalkyl, NH(C.sub.1-4alkylOC.sub.1-4alkoxy), NH(C.sub.1-4alkyl), N(C.sub.1-4alkyl).sub.2, OC(O)NR.sub.9R.sub.8, NR.sub.8C(O)R.sub.9 or C(O)NR.sub.9R.sub.8; R.sub.9 and R.sub.8 independently represent hydrogen, C.sub.1-4 alkyl or C.sub.3-7 cycloalkyl; m represents zero or an integer from 1 to 4; n represents 1 or 2; p is zero or an integer from 1 to 3; q is an integer from 1 to 3; r is an integer from 1 to 4; t is 0, 1 or 2; provided that when m is 0, p is 2, q , r and n represent 1, R.sub.1, R.sub.2,R.sub.3, R.sub.4, R.sub.5 and R.sub.7 are hydrogen and R is chlorine, R.sub.5 is not iodine; and pharmaceutically acceptable salts and solvates thereof; process for their preparation and their use in the treatment of conditions mediated by tackykinins and/or by selective inhibition of serotonin reuptake transporter protein.