The present invention relates to an interventional procedure simulation system and method, comprising a control unit and an interface unit, said control unit communicating with said interface unit to simulate handling of at least one instrument interfaced by said interface unit. The control unit comprises a database of vessels having hierarchy structure, each vessel having a diameter and a stiffness, and said instrument being a tool expendable in a simulated vessel. When the tool is expanded, a geometry of said vessel changes resulting in a fluid flow change.