The invention relates to 4-cyanopyrazole-3-carboxamide derivatives of formula (I): in which R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8 are as described herein. Also disclosed and claimed are the method of preparation and therapeutic application of compound of formula (I).