The present invention relates to a GLP-1 peptide having the following
formula, or a pharmaceutically acceptable salt thereof:
X-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-
-Ala-Lys-Glu-Phe-lle-Ala-Trp-Leu-val-Lys-Gly-Arg-Y (SEQ ID NO. 1)
wherein X is a rigidifying hydrophobic moiety and wherein Y is selected
from the group consisting of OH, NH.sub.2 and Gly-OH. Moreover, the
present invention relates to pharmaceutical compositions comprising a
therapeutically effective amount of a peptide of the present invention,
or a pharmaceutically acceptable salt thereof, in association with at
least one constituent selected from a pharmaceutically acceptable
carrier, diluent, and excipient.