Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-.alpha. (TNF.alpha.) and are useful in vivo diagnosis and therapy of a number of TNF.alpha.-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.

 
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< Spiro-cyclic -amino acid derivatives as inhibitors of matrix metalloproteases and TNF- converting enzyme (TACE)

< (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof

> Small molecular weight TNF receptor multimeric molecule

> Triazolone and triazolethione derivatives as inhibitors of matrix metalloproteinases and/or TNF-.alpha. converting enzyme

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