A low profile gastrointestinal tube feeding system having a securing member for securing a feeding set to a low profile gastrostomy tube disposed inside a visceral organ of a patient's body so that inadvertent removal of the feeding set from the gastrostomy tube is prevented. Also provided is a securing member that secures a connection member to an external retention member. Once the securing member has connected the connection member to the external retention member, neither the connection member nor the external retention member can be separated from one another until the securing member is first disengaged from either member.