An objective of the present invention is to provide methods for
efficiently producing (S)-1-(3,4-dimethoxyphenyl)-2-propanol at a high
optical purity. Another objective is to provide novel reductases which
reduce 3,4-dimethoxyphenylacetone, using NADPH as a coenzyme, to produce
(S)-1-(3,4-dimethoxyphenyl)-2-propanol with a high optical purity.The
inventors found that a 3,4-dimethoxyphenylacetone-reducing enzyme present
in Torulaspora delbrueckii is a novel carbonyl reductase that reduces
various carbonyls. This novel enzyme reduces 3,4-dimethoxyphenylacetone
in a reduction reaction to produce (S)-1-(3,4-dimethoxyphenyl)-2-propanol
with a high optical purity and at a high yield. Furthermore, the
inventors isolated a DNA that encodes the present enzyme, and generated a
recombinant bacterium which highly expresses the present enzyme. Thus,
the present inventors established a simple and highly economical method
of obtaining optically active alcohols with a high optical purity and at
a high yield.