The present invention relates to a photosensitive device comprising a matrix of photosensitive pixels, in particular of the type produced by techniques for depositing semiconductor materials. The invention relates more particularly (but not exclusively) to the driving of such devices used for detecting radiological images. It also relates to a method of driving the photosensitive device.The photosensitive device includes means for adjusting the amplitude of the bias, allowing separate adjustment of the amplitude of the bias of the photosensitive pixels (P1 to P9; P401 to P409).The method of driving the photosensitive device consists, in the calibration phase, in adjusting the amplitude of the bias of each of the photodetector elements (Dp) separately from one another, so as to bring the output saturation levels of the two photosensitive pixels into maximum coincidence.