In a turbo-molecular pump with a high vacuum-side induction area and of a rotational symmetrical arrangement, comprising a compressor turbine including a rotor and a stator tube having axially alternately tightly arranged rotor blade rings and stator vane rings with oppositely oriented blade and vane surfaces, a pre-vacuum chamber with a gas guide structure for the connection of a pre-pumping system, a drive module and a bearing unit, the turbo-molecular pump has a center area with a central coaxial open space extending from an ambient end to the high vacuum-side induction area and the open space is closed at its end adjacent the ambient end thereof by a flange in a vacuum-tight manner or is connected to a vacuum recipient, and the high-vacuum end of this space is separated from a pre-vacuum space.