An ECG signal detection device that includes a differential amplifier input circuit and a driven reference electrode lead is disclosed. More specifically, the ECG signal detection device includes a differential amplifier input circuit and three-electrode leads, two of which terminate at a common patient coupling device such as an electrode pad or a defibrillator paddle. The third electrode lead terminates at a second, separate patient coupling device. Two electrical cords that include the electrode leads extend between the patient coupling devices and the differential amplifier input circuit. One electrical cord includes the two-electrode leads that terminate at the common patient coupling device. One electrode lead and an associated electrode integrated into the common patient coupling device form one of the ECG signal inputs to the differential amplifier and the second electrode lead and an associated electrode also integrated into the common patient coupling device form a driven reference input to the differential amplifier. The other electrode cord incorporates the third electrode lead. The third electrode lead and an associated electrode integrated into the second, separate patient coupling device form the other ECG signal input to the differential amplifier.