Compounds comprising ##STR00001## are disclosed, wherein Y, A, X, R, D, and n are as described.A compound comprising a prostaglandin EP.sub.2 selective agonist wherein the .omega.-chain comprises a substituted phenyl, wherein at least one substituent consists of hydrocarbyl or non-linear hydroxyhydrocarbyl is also disclosed herein.Methods, compositions, and medicaments related thereto are also disclosed.