There is provided a production method for producing a biarylalanine compound of formula (4): ##STR00001## wherein R.sup.1 represents a amino protective group and R.sup.2 represents an amino protective group or a hydrogen atom, R.sup.3 is a carboxy protective group, or the like, and R.sup.4 is a substituted or unsubstituted aryl or heteroaryl group, characterized by reacting an aromatic amino acid of formula (1) ##STR00002## wherein X is a halogen atom or a trifluoromethanesulfonyloxy group, and R.sub.1, R.sup.2 and R.sup.3 has the same meaning as defined above, with an organic boron compound of formula (2): ##STR00003## wherein R.sup.4 has the same meaning as defined above, and Q.sup.1 and Q.sup.2 are the same or different and each is a hydroxy group, an alkoxy group having 1 to 4 carbon atom(s), in the presence of nickel catalyst and a base.