The present invention is related to the fields of molecular biology,
virology, immunology and medicine. The invention provides a composition
comprising an ordered and repetitive antigen or antigenic determinant
array, and in particular an array comprising a protein or peptide of
IL-5, IL-13 or eotaxin. More specifically, the invention provides a
composition comprising a virus-like particle and at least one protein, or
peptide of IL-5, IL-13 and/or eotaxin bound thereto. The invention also
provides a process for producing the conjugates and the ordered and
repetitive arrays, respectively. The compositions of the invention are
useful in the production of vaccines for the treatment of allergic
diseases with an eosinophilic component and as a pharmaccine to prevent
or cure allergic diseases with an eosinophilic component and to
efficiently induce immune responses, in particular antibody responses.
Furthermore, the compositions of the invention are particularly useful to
efficiently induce self-specific immune responses within the indicated
context.