This invention relates to a bone implant that includes a bioinert
substrate covered with a ceramic layer containing a plurality of
indentations. The total surface area of the indentations is 30-70% of the
total surface area of the ceramic layer. This invention also relates to a
method of preparing such a bone implant. The method includes: (1)
affixing a ceramic layer on the surface of a bioinert substrate; (2)
forming a plurality of indentations in the ceramic layer, wherein the
total surface area of the indentations is 30-70% of the total surface
area of the ceramic layer; and (3) immobilizing a biopolymer onto the
ceramic layer via covalent bonding.